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                          September 12, 2022

       Gerard Michel
       Chief Executive Officer
       Delcath Systems, Inc.
       1633 Broadway, Suite 22C
       New York, New York 10019

                                                        Re: Delcath Systems,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed September 7,
2022
                                                            File No. 333-267321

       Dear Mr. Michel:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tim
Buchmiller at (202) 551-3635 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Nicolas H.R. Dumont,
Esq.